PB28 dihydrochloride

Research use only, not for human use.

σ2 receptor agonist

PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity.

Cell Viability Assay Cell Line:MCF7 and MCF7 ADR cells Concentration:25 nM and 15 nM Incubation Time:24 hours, 48 hours Result:Showed an accumulation in the G0-G1 phase for MCF7 and MCF7 ADR cells that were time and concentration independent.

Animal Model:C57BL/6 female mice (10 weeks old) injected with Panc02 cells Dosage:10.7 mg/mL Administration:Intraperitoneal injection; daily; for two weeks Result:Inhibited tumor growth in Panc02 tumor burden mice.

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Others

Other Targets

Others

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172907-03-8

443.49

C24H40Cl2N2O

>98% (HPLC)

In Vitro:? H2O : 9 mg/mL (20.29 mM)DMSO : 5 mg/mL (11.27 mM; Ultrasonic (<60°C); )

COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years